Haplostrips : revealing population structure through haplotype visualization
نویسندگان
چکیده
منابع مشابه
Population structure with localized haplotype clusters.
We propose a multilocus version of F(ST) and a measure of haplotype diversity using localized haplotype clusters. Specifically, we use haplotype clusters identified with BEAGLE, which is a program implementing a hidden Markov model for localized haplotype clustering and performing several functions including inference of haplotype phase. We apply this methodology to HapMap phase 3 data. With th...
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The advent of genome-wide dense variation data provides an opportunity to investigate ancestry in unprecedented detail, but presents new statistical challenges. We propose a novel inference framework that aims to efficiently capture information on population structure provided by patterns of haplotype similarity. Each individual in a sample is considered in turn as a recipient, whose chromosome...
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This chapter consists of five parts. In the first part, we provide definitions for important terms and concepts used in studies of population haplotype structures. In the second part, we introduce the user to valuable publicly available genotype/haplotype databases, such as databases generated by the International HapMap Project. In the third part, we provide concise guides to the user on how t...
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MOTIVATION Understanding haplotype evolution subject to mutation, recombination and gene conversion is fundamental to understand genetic specificities of human populations and hereditary bases of complex disorders. The goal of this project is to develop new algorithmic tools assisting the reconstruction of historical relationships between haplotypes and the inference of haplotypes from genotype...
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ژورنال
عنوان ژورنال: Methods in Ecology and Evolution
سال: 2017
ISSN: 2041-210X,2041-210X
DOI: 10.1111/2041-210x.12747